The earliest records of Lentvaris Manor date back to the second half of the 16th century, when Sigismund Augustus (1520–1572) confirmed the then Litavariškės as the property of Kazimierz Kmita Kuncewicz. In 1604 Jan Kmita's daughter Beata Komorowska sold the manor to Adam Kijanowski, and in 1618 the Vice-Chancellor of the Grand Duchy of Lithuania, Paweł Stefan Sapieha (1565–1635), acquired it from the Kijanowskis. In 1670 Anna Sapieha Naruszewicz bequeathed the manor in her will to the Benedictine convent in Vilnius. In the mid-18th century the manor was bought by Michał Antoniewicz, who in 1772 gave it to his nephew Antoni Hryniewicz. In 1819, by court decision, the manor was divided among his descendants. Until the mid-19th century the area is mentioned as the property of the Lapp, Izdebski and Szachno families. In the 1850s Count Józef Tyszkiewicz (1830–1891), one of the wealthiest landowners in Lithuania, acquired the manor and set up a residence here with a park and buildings for horse breeding. Józef Tyszkiewicz invested part of his capital in industry and trade, building a wire and nail factory in Lentvaris. In 1892 the manor was inherited by his son Władysław Tyszkiewicz (1865–1936) – a lawyer, dentist, public figure and collector who was active in social and political life. In 1899 he rebuilt the inherited Lentvaris Manor, extended the park and laid out tennis courts. In 1907 he founded a summer kindergarten in Lentvaris for the children of Vilnius townspeople, and in 1897–1926 he was the main founder of the Church of the Annunciation of the Blessed Virgin Mary. While living in Milan he opened the antique shop "Warowland" (a distorted form of Landwarów, the Polish name for Lentvaris) and assembled a large collection of cultural, artistic and scientific treasures, which he later brought back to Lentvaris. Wishing to introduce the public to the art collections, in 1907 he established the Society of the Museum of Science and Art in Vilnius, involving his brothers Antoni and Józef Tyszkiewicz, the architect Tadeusz Rostworowski (1860–1928), Count Marian Broel-Plater (1873–1951), the archaeologist Wandalin Szukiewicz and the painter Bolesław Michał Rusiecki (1824–1913). The museum exhibited archaeological, numismatic, ethnographic and art collections donated by the society's founding members and supporters. Most of the collections consisted of a collection of Western European paintings donated by W. Tyszkiewicz. In 1914 the society merged with the Vilnius Society of Friends of Learning, whose art collections were taken over by the Lithuanian Art Museum in 1941. Much of the collection kept in Lentvaris was taken to Warsaw between the wars. Most of it was destroyed in 1944 during the Warsaw Uprising against the Germans. In 1915–1920, during the campaigns of various armies, the manor farm was destroyed. In 1920–1939 Lentvaris belonged to the Vilnius Region under Polish rule. Fearing a resumption of hostilities on the Polish–Lithuanian border, the Tyszkiewicz family did not try to spend much on renovating the residence, and the palace was mothballed. After W. Tyszkiewicz's death, the last owner of Lentvaris was his son Stefan Eugeniusz Maria Tyszkiewicz (1897–1976), who owned the manor and lived in it until 1939. During the Second World War the manor housed military headquarters; after the war, a collective farm; and from 1957 the former counts' palace housed the administration of the Lentvaris carpet factory. In 2007 the manor was bought by the businessman Laimutis Pinkevičius, who went bankrupt the same year. Lentvaris Manor was mortgaged in 2007 and seized in 2012. In 2016 the businessman Ugnius Kiguolis bought the manor at auction.